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Free trial offer for up to 42 TOPAMAX 25 mg tablets I am ready to help stop my migraine attacks before they start. Is TOPAMAX right for me? Just follow these 3 easy steps: To the Patient: l Talk to your doctor to find out if TOPAMAX is right for you. TOPAMAX is available by prescription only 2. If your doctor prescribes TOPAMAX, you can get up to 42125 mg) tablets free from your pharmacist with this offer. 3. Present your written prescription for up to 42 TOPAMAX 25 mg tablets AND this voucher to your pharmacist to receive your free trial of TOPAMAX. In order to process your voucher, please read and sign below. • By signing and dating below, you understand and consent that your persona! information will be used and disclosed to vendors working on behalf of Ortho-McNeil Neurologies, Inc., solely to administer reimbursement to your pharmacy and/or verify compliance with program rules and restrictions. Patient's Signature Date Conditions of Use: • Limited to 1 TOPAMAX free trial voucher redemption per person. USA WEEKEND ORDERCARD IMPORTANT SAFETY INFORMATION Serious risks associated with TOPAMAX include lowered bicarbonate levels in the blood resulting in an increase in the acidity of the blood (metabolic acidosis). Symptoms could include hyperventilation (rapid, deep breathing), tiredness, loss of appetite, irregular heartbeat or changes in the level of alertness. Call your doctor immediately if you get these symptoms. Your doctor may want to do simple blood tests. Chronic, untreated metabolic acidosis may increase the risk for kidney stones or bone disease. CP ORTMO-McrtK NtußOLOGics. ©OMN, Inc. 2007 October 2007 02M851R2 ■ i JT;..' . •KSffiSr FREE TRIAL OFFER • Ortho-McNeil Neurologies Inc , reserves the right to rescind, revoke, or amend this offer at any time without notice • This voucher is not valid through mail-order pharmacies • Subject to eligibility restrictions listed on the face of this voucher. To the Physician: • In order to use this voucher, your patient will require a valid signed prescription for up to 42 TOPAMAX 25 mg tablets • Please provide your patient with a separate prescription if you wish them to continue beyond this trial. • Also refer to eligibility restrictions Other serieus risks include decreased sweating, increased body temperature, kidney stones, sleepiness, dizziness, confusion, difficulty concentrating, and increased eye pressure (glaucoma) Call your doctor immediately if you have any decrease in vision or eye pain. These problems can lead to blindness if not treated right away. More common side effects are tingling in arms and legs, loss of appetite, tiredness, nausea, diarrhea, taste change and weight loss. Tell your doctor about other medications you take. msm. . Thinking fibout migraines even when you're not having one? Maybe it's time for a change. PRINTED IN USA Please see important product information about TOPAMAX on adjacent page. ip stop migraines before they start or of them to think about. It’s believed rips “calm” overexcitable nerve cells ic attack. differently from the treatments t hint of a migraine. It’s a daily ition. h your doctor of how migraines if TOPAMAX is right for you. ft be completely eliminated, ange you’re looking for. .ause side effects. Please see ETY INFORMATION below. com for tips on living iys revolve around migraines. TOPAMAX’ (topiramate) Tablets after it starts. Tosjetber Hi Access and ! the TujetiNK «> Access fooc trademarts of Tegetw »* Access. U.C.