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CELEBREX® (ceiecoxib capsules) Medication Guide for Non-Steroidal Anti-lnflammatorv Drugs (NSAIDs) (Sec the end of this Medication Guide for a list of prescription NSAID medicines.) What is the most important information I should know about medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)? NSAID medicines may increase the chance of a heart attack or stroke that can lead to death. This chance increases: • with longer use of NSAID medicines • in people who have heart disease NSAID medicines should never be used right before or after a heart surgery called a “coronary artery bypass graft (CABG).” NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment Ulcers and bleeding: • can happen without warning symptoms • may cause death The chance of a person getting an ulcer or bleeding increases with: • taking medicines called “corticosteroids” and “anticoagulants” • longer use • smoking • drinking alcohol • older age • having poor health NSAID medicines should only be used: • exactly as prescribed • at the lowest dose possible for your treatment • for the shortest time needed What are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)? NSAID medicines are used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as: • different types of arthritis • menstrual cramps and other types of short-term pain Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)? Do not take an NSAID medicine: • if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine • for pain right before or after heart bypass surgery Tell your healthcare provider: • about all of your medical conditions. • about all of the medicines you take. NSAIDs and some other medicines can interact with each other and cause serious side effects. Keep a list of your medicines to show to your healthcare provider and pharmacist • if you are pregnant. NSAID medicines should not be used by pregnant women late in their pregnancy. • if you are breastfeeding. Talk to your doctor. What are the possible side effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)? Serious side effects include: • heart attack • stroke • high blood pressure • heart failure from body swelling (fluid retention) • kidney problems including kidney failure • bleeding and ulcers in the stomach and intestine • low red blood cells (anemia) • life-threatening skin reactions • life-threatening allergic reactions • liver problems including liver failure • asthma attacks in people who have asthma Other side effects include: • stomach pain • constipation • diarrhea • gas • heartburn • nausea • vomiting • dizziness Get emergency help right away if you have any of the following symptoms: • shortness of breath or trouble breathing • chest pain • weakness in one part or side of your body Stop your NSAID medicine and call your healthcare provider right away if you have any of the following symptoms: • nausea • more tired or weaker than usual • itching • your skin or eyes look yellow • stomach pain • flu-like symptoms • vomit blood These are not all the side effects with NSAID medicines. Talk to your healthcare provider or pharmacist for more information about NSAID medicines. Other information about Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) • Aspirin is an NSAID medicine but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines. • Some of these NSAID medicines are sold in lower doses without a prescription (over-the-counter). Talk to your healthcare provider before using over-the-counter NSAIDs for more than 10 days. NSAID medicines that need a prescription Generic Name Tradename Ceiecoxib Celebrex Diclofenac Cataflam, Voltaren, Arthrotec (combined with misoprostol) Diflunisal Dolobid Etodolac Lodine, Lodine XL Fenoprofen Nalfon, Nalfon 200 Flurbiprofen Ansaid l blJDrofen Motrin, Tab-Profen, Vicoprofen* (combined with hydrocodone), Combunox (combined with oxycodone) Indomethacin Indocin, Indocin SR, Indo-Lemmon, Indomethagan Ketoprofen Oruvail Ketorolac Toradol Mefenamic Acid Ponstel Meloxicam Mobic Nabumetone Relafen NaDroxen Naprosyn, Anaprox, Anaprox DS, EC-Naproxyn, Naprelan, Naprapac (copackaged with lansoprazole) Oxaprozin Daypro Piroxicam Feldene Sulindac Clinoril Tolmetin Tolectin, Tolectin DS, Tolectin 600 ’Vicoprofen contains the same dose of ibuprofen as over-the-counter (OTC) NSAIDs, and is usually used for less than 10 days to treat pain. The OTC NSAID label warns that long term continuous use may increase the risk of heart attack or stroke. This Medication Guide has been approved by the U.S. Food and Drug Administration. Distributed by G.D. Scarle LLc"""""" Division of Pfizer me. NY, NY 10017 LAB-0324-2.0 © 2007 Pfizer Inc. All rights reserved. CLUOOO34W Issued February 2007 • slurred speech • swelling of the face or throat • there is blood in your bowel movement or it is black and sticky like tar • skin rash or blisters with fever • unusual weight gain • swelling of the arms and legs, hands and feet THE YEAR THAT WAS Top celebs plenty this year—extensively for USA WEEKEND readers. When we put the two biggest High School Musical stars on our cover in August, their futures seemed limitless. A month later, Vanessa Hudgens said on The Tyra Banks Show what she thought of Brit ney Spears’ and Lindsay Lohan’s bad behavior: “I honestly just think it’s stu pid. ... It’s easy to stay out of those situa tions.” The pretaped show aired a few days after Hudgens got slammed with a mini-scandal of her own some sug gestive photos on the Web. Meanwhile, real-life love Zac Efron showed his abs on the cover of Rolling Stone, but the teen heartthrob has his eyes on filling some respectable (and large) Hollywood shoes: There has been talk that he might take up Kevin Bacon's role in a Footloose remake, and he’s starring in the upcom ing Seventeen, a modern-day Big, for which Tom Hanks was nominated for an Oscar in the ’Bos They say everyone comes home again. It may be that time musically speaking, at least. When we talked to Kelly Clarkson in July, in the heat of a well-publicized battle over creative differences with her label, she opened up about her true feelings for its chief, Clive Davis: “lam not a fan... and, despite the rumors, he is nowhere near a father figure.” (A week later, she apologized on her website.) Her fussed over album has had mediocre sales, and now Clarkson appears to be switching musical gears to get back to her South ern roots: She hired pal Reba McEn tire’s husband to manage her, recorded the country-tinged duet Became of You with McEntire and last month announced that the two will go on tour together in January ... When Cameron Diaz and Continues on page 25 20 USA WEEKEND • Dec 28-30,2007